Animal copy reports have not been performed With all the drug combination–promethazine and phenylephrine. It's not at all acknowledged no matter whether this drug blend can cause fetal hurt when administered to some Expecting lady or can have an effect on replica capacity. Promethazine and phenylephrine should be given to a pregnant woman only if Evidently needed.
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Stimulation can be apparent, particularly in children and geriatric sufferers. Convulsions could not often take place. A paradoxical response has been reported in little ones acquiring one doses of 75 mg to 125 mg orally, mcharacterized by hyperexcitability and nightmares.
Akorn lean refers to the misuse of Akorn promethazine-codeine syrup in lean drinks. Buyers blend the syrup with soda and candy to create a sweet, sedative beverage.
Bone-Marrow Melancholy: Promethazine should be employed with warning in check here sufferers with bone-marrow depression. Leukopenia and agranulocytosis are claimed, usually when promethazine HCl has long been Employed in Affiliation with other identified marrow-harmful agents.
There are two various formulations out there. They meet up with certain affected person wants and give Health care suppliers solutions in cure.
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Akorn is devoted to bettering affected person treatment. This is obvious during the mindful development in their new promethazine syrup formulations.
Promethazine hydrochloride occurs for a white to faint yellow, pretty much odorless, crystalline powder which gradually oxidizes and turns blue on extended publicity to air.
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Therapeutic doses of phenylephrine generally cause vasoconstriction. Phenylephrine boosts resistance and, to some lesser extent, decreases capacitance of blood vessels. Whole peripheral resistance is increased, causing increased systolic and diastolic blood pressure level. Pulmonary arterial strain will likely be greater, and renal blood flow is usually lowered. Local vasoconstriction and hemostasis happen following topical application or infiltration of phenylephrine into tissues.
This products has several variants. The options might be chosen on the item site Merchandise types
If this SPL incorporates inactivated NDCs listed through the FDA initiated compliance motion, They are going to be specified as a result.
Promethazine hydrochloride and phenylephrine hydrochloride syrup should be employed with caution in pediatric clients 2 a long time of age and older (see WARNINGS-Use in Pediatric Sufferers)